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Minnelide (14-O-phosphonooxymethyltriptolide disodium salt) Catalog No. H5637

Minnelide

CAS No.: 1254702-87-8

Minnelide(14-O-phosphonooxymethyltriptolide disodium salt)

Catalog No.: H5637

A water-soluble prodrug of triptolide that is highly effective in reducing pancreatic tumor growth and spread, and improving survival

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5 mg USD 235 In stock
25 mg USD 810 In stock
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Purity & Documentation Purity: 98% (HPLC) Select Batch:

Biological Activity

A water-soluble prodrug of triptolide that is highly effective in reducing pancreatic tumor growth and spread, and improving survival; efficiently downregulates both CD133(-) and CD133(+) population in the tumors, resulting in a 60% decrease in tumor volume; also is very effective as a therapeutic option against Castration Resistant Prostate Cancer (CRPC).

References

1. Chugh R, et al. Sci Transl Med. 2012 Oct 17;4(156):156ra139.


2. Banerjee S, et al. Clin Cancer Res. 2014 May 1;20(9):2388-99.


3. Isharwal S, et al. Prostate. 2017 May;77(6):584-596.

Clinical Information

Pancreatic Cancer
Phase 2 Clinical

Physicochemical Properties

M.Wt 514.374
Formula C21H25Na2O10P
CAS No. 1254702-87-8
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Chemical Name/SMILES sodium (((5bS,6aS,7aR,8R,8aS,9aS,9bS,10aS,10bS)-8a-isopropyl-10b-methyl-3-oxo-1,2,3,5,5b,6,6a,8,8a,9a,9b,10b-dodecahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-8-yl)oxy)methyl phosphate

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TAK1 Pancreatic Cancer
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