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PI4KIIIbeta-IN-10 (N-5-3-N-4-hydroxyphenylsulfamoyl-4-methoxyphenyl-4-methylthiazol-2-ylpivalamide) Catalog No. H7104

PI4KIIIbeta-IN-10

CAS No.: 1881233-39-1

PI4KIIIbeta-IN-10(N-5-3-N-4-hydroxyphenylsulfamoyl-4-methoxyphenyl-4-methylthiazol-2-ylpivalamide)

Catalog No.: H7104

A potent and selective type III phosphatidylinositol 4-kinase (PI4KIIIβ) inhibitor with IC50 of 3.6 nM

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5 mg USD 343 In stock
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Purity & Documentation Purity: 98% (HPLC) Select Batch:

Biological Activity

A potent and selective type III phosphatidylinositol 4-kinase (PI4KIIIβ) inhibitor with IC50 of 3.6 nM; displays >200-fold selectivity over class I and class III PI3Ks; shows antiviral activity against hepatitis C virus with IC50 of 1.3 uM, with low cytotoxicity (CC50>32 uM).

References

1. Rutaganira FU, et al. J Med Chem. 2016 Mar 10;59(5):1830-9.

Physicochemical Properties

M.Wt 475.581
Formula C22H25N3O5S2
CAS No. 1881233-39-1
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

DMSO: ≥ 30 mg/mL
Chemical Name/SMILES N-(5-(3-(N-(4-hydroxyphenyl)sulfamoyl)-4-methoxyphenyl)-4-methylthiazol-2-yl)pivalamide

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