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Shield-1 (Shld-1;Shield 1;Shield 1) Catalog No. H6688

Shield-1

CAS No.: 914805-33-7

Shield-1(Shld-1;Shield 1;Shield 1)

Catalog No.: H6688

A cell-permeable FKBP ligand that is designed to protect an otherwise unstable protein domain from degradation

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Purity & Documentation Purity: 98% (HPLC) Select Batch:

Biological Activity

A cell-permeable FKBP ligand that is designed to protect an otherwise unstable protein domain from degradation; binds tightly to FKBP, induces rapid and processive degradation of the LID domain and any fused partner protein.

References

1. Banaszynski, et al. Cell. 2006 Sep 8; 126(5):995-1004.


2. Rodriguez S, et al. Chem Biol. 2012 Mar 23;19(3):391-8.


3. Bonger KM, et al. Nat Chem Biol. 2011 Jul 3;7(8):531-7.

Physicochemical Properties

M.Wt 748.9
Formula C42H56N2O10
CAS No. 914805-33-7
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Chemical Name/SMILES (S)-(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl) propyl 1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

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