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TEPP-46 (ML-265) Catalog No. H6828

TEPP-46

CAS No.: 1221186-53-3

TEPP-46(ML-265)

Catalog No.: H6828

A potent activator of PKM2 (pyruvate kinase M2) with IC50 of 92 nM

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Purity & Documentation Purity: 98% (HPLC) Select Batch:

Biological Activity

A potent activator of PKM2 (pyruvate kinase M2) with IC50 of 92 nM; shows no activity on PKM1 in vitro; binds to PKM2 at the subunit interaction interface site that is distinct from that of the endogenous activator FBP; inhibits xenograft tumor growth and orally bioactive.

References

1. Anastasiou D, et al. Nat Chem Biol. 2012 Oct;8(10):839-47.


2. Qi W, et al. Nat Med. 2017 Apr 24. doi: 10.1038/nm.4328.


3. Witney TH, et al. Sci Transl Med. 2015 Oct 21;7(310):310ra169.

Physicochemical Properties

M.Wt 372.4645
Formula C17H16N4O2S2
CAS No. 1221186-53-3
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

DMSO: ≥ 28 mg/mL
Chemical Name/SMILES 5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one, 6-[(3-aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-

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Pyruvate Kinase
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